Rheumatoid Arthritis Risk Allele PTPRC Is Also Associated With Response to Anti-Tumor Necrosis Factor α Therapy.

The article presents a study which examined the response of rheumatoid arthritis risk allele PTPRC to anti-tumor necrosis factor (TNF) alpha therapy. According to the authors, there was strong statistical evidence favoring the association of PTPRC single-nucleotide polymorphism with response to anti-TNF-alpha therapy in patients who were seropositive for either rheumatoid factor and anti-citrullinated protein autoantibodies. They explain that age, sex and drugs were analyzed as correlates of treatment response.