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Primary chronic myelofibrosis: clinical and prognostic evaluation in 336 Japanese patients.
- Source :
- International Journal of Hematology; Feb2001, Vol. 73 Issue 2, p194-198, 5p
- Publication Year :
- 2001
-
Abstract
- We retrospectively analyzed 336 patients with primary chronic myelofibrosis from 203 medical institutes in Japan. Notwithstanding their heterogeneous treatments, the median survival in 298 patients that could be evaluated was 10.0 years. Average age at onset was 60.7 years. Men were affected 1.4 times more frequently than women. The factors associated with shorter survival included anemia, leukocytosis/leukocytopenia, thrombocytopenia, and increased blasts in the peripheral blood, and sex (male), age (>60), and the presence of symptoms. A new scoring system based on the peripheral blood findings (hemoglobin [Hb] level, platelet count, and rate of blast formation) at initial diagnosis clearly correlated with survival rate. Accordingly, patients could be categorized into 3 groups by severity grading. Through stepwise multivariate survival analysis, the significant prognostic factors were identified as the severity grading based on the new scoring system (P = .0002), age (P = .0024), sex (P = .0153), and Hb (P = .0198). Chromosomal abnormalities were found in 58 of 154 patients (38%), although these did not influence survival. [ABSTRACT FROM AUTHOR]
- Subjects :
- AGE distribution
CHROMOSOME abnormalities
CHRONIC diseases
COMPARATIVE studies
LONGITUDINAL method
RESEARCH methodology
MEDICAL cooperation
MYELOFIBROSIS
PROGNOSIS
RESEARCH
SEX distribution
SURVIVAL analysis (Biometry)
SURVIVAL
EVALUATION research
ACQUISITION of data
RETROSPECTIVE studies
DIAGNOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 09255710
- Volume :
- 73
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- International Journal of Hematology
- Publication Type :
- Academic Journal
- Accession number :
- 52576431
- Full Text :
- https://doi.org/10.1007/BF02981937