Back to Search
Start Over
Ulinastatin, an elastase inhibitor, inhibits the increased mRNA expression of prostaglandin H2 synthase-type 2 in Kawasaki disease.
- Source :
- Journal of Infectious Diseases; 3/1/2000, Vol. 181 Issue 3, p1101-1109, 9p
- Publication Year :
- 2000
-
Abstract
- Kawasaki disease is an inflammatory disease of unknown cause that causes panvasculitis, including coronary arteritis. Polymorphonucleocytosis in the early stage of the illness suggests the implication of neutrophils in the pathogenesis of the disease. In the acute phase of Kawasaki disease, mRNA expression of prostaglandin H2 synthase (PHS)-2, as determined by reverse transcription-polymerase chain reaction, was markedly enhanced, and thromboxane A2 (TXA2)-synthesizing activity was increased in polymorphonuclear leukocytes (PMNL). This up-regulation of PHS-2 was suppressed by ulinastatin (a neutrophil-elastase inhibitor) treatment. Lipopolysaccharide-induced enhancement of PHS-2 mRNA was also inhibited by therapeutic doses of ulinastatin in vitro by use of PMNL from healthy volunteers. Thus, ulinastatin inhibits arachidonate PHS metabolism by inhibiting new induction of PHS-2 at the mRNA level, which is a novel pharmacologic action of this substance. Ulinastatin treatment is possibly an additional therapeutic approach to Kawasaki disease. [ABSTRACT FROM AUTHOR]
- Subjects :
- ELASTASES
PROSTAGLANDINS
MUCOCUTANEOUS lymph node syndrome
CHEMICAL inhibitors
PHYSIOLOGY
SECRETION
RNA analysis
ASPIRIN
COMPARATIVE studies
ENZYMES
ESTERASES
GLYCOPROTEINS
ISOENZYMES
RESEARCH methodology
MEDICAL cooperation
NEUTROPHILS
OXIDOREDUCTASES
PROTEOLYTIC enzymes
RESEARCH
THROMBOXANES
EVALUATION research
LIPOPOLYSACCHARIDES
PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 181
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 5256544
- Full Text :
- https://doi.org/10.1086/315332