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The Removal of Beta-2-microglobulin by an Immunoadsorption Wall.
The Removal of Beta-2-microglobulin by an Immunoadsorption Wall.
- Source :
- Artificial Organs; Feb99, Vol. 23 Issue 2, p131-138, 8p, 5 Diagrams, 1 Chart, 3 Graphs
- Publication Year :
- 1999
-
Abstract
- The accumulation of beta-2-microglobulin (β<subscript>2</subscript>M) in collagen-rich tissues has been proven to be the main cause of dialysis related amyloidosis. However, it remains uncertain which technique for the removal of β<subscript>2</subscript>M can be used without compromising the advantages of other dialysis strategies. A new concept, an immunoadsorption wall, which combines the principles of immunoisolation and immunoadsorption is proposed to remove β<subscript>2</subscript>M. The present investigations suggested that the application of the concept to clinical use is feasible and worthwhile. The concept, if validated, will help shape a novel multitask type of artificial kidney based on the combination of different separation technologies. [ABSTRACT FROM AUTHOR]
- Subjects :
- AMYLOIDOSIS
DIALYSIS (Chemistry)
IMMUNOADSORPTION
Subjects
Details
- Language :
- English
- ISSN :
- 0160564X
- Volume :
- 23
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Artificial Organs
- Publication Type :
- Academic Journal
- Accession number :
- 5242673
- Full Text :
- https://doi.org/10.1046/j.1525-1594.1999.06207.x