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The Removal of Beta-2-microglobulin by an Immunoadsorption Wall.

The Removal of Beta-2-microglobulin by an Immunoadsorption Wall.

Authors :
Yang, Tsung Hua
Lee, Chau Jen
Chu, I Ming
Hwang, Jyh Chang
Yang, Tsung Lin
Source :
Artificial Organs; Feb99, Vol. 23 Issue 2, p131-138, 8p, 5 Diagrams, 1 Chart, 3 Graphs
Publication Year :
1999

Abstract

The accumulation of beta-2-microglobulin (β<subscript>2</subscript>M) in collagen-rich tissues has been proven to be the main cause of dialysis related amyloidosis. However, it remains uncertain which technique for the removal of β<subscript>2</subscript>M can be used without compromising the advantages of other dialysis strategies. A new concept, an immunoadsorption wall, which combines the principles of immunoisolation and immunoadsorption is proposed to remove β<subscript>2</subscript>M. The present investigations suggested that the application of the concept to clinical use is feasible and worthwhile. The concept, if validated, will help shape a novel multitask type of artificial kidney based on the combination of different separation technologies. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
0160564X
Volume :
23
Issue :
2
Database :
Complementary Index
Journal :
Artificial Organs
Publication Type :
Academic Journal
Accession number :
5242673
Full Text :
https://doi.org/10.1046/j.1525-1594.1999.06207.x