Physiological hypoxia promotes lipid raft and PI3K-dependent activation of MAPK 42/44 in leukemia cells.

Authors :: Fiegl, M.
Samudio, I.
Mnjoyan, Z.
Korchin, B.
Fritsche, H.
Andreeff, M.
Source :: Leukemia (08876924); Jul2010, Vol. 24 Issue 7, p1364-1367, 4p, 1 Diagram, 1 Graph
Publication Year :: 2010
Abstract: The article presents a study to examine the effect of physiological hypoxia in leukemia cells. It observes that the functional consequences of mitogen-activated protein kinases (MAPK) activation on acute myeloid leukemia cells (AML) adjusted to hypoxic conditions. It concludes that the physiological hypoxia helps in promoting lipid raft and PI3K-regulated mechanism of MAPK 42/44 in leukemia cells.

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