Is there a role for endothelin antagonists in diabetic renal disease?

Authors :: Jandeleit-Dahm, Karin
Allen, Terri J.
Youssef, Sherif
Gilbert, Richard E.
Cooper, Mark E.
Source :: Diabetes, Obesity & Metabolism; Jan2000, Vol. 2 Issue 1, p15-24, 10p
Publication Year :: 2000
Abstract: Evaluates the role for endothelin (ET) antagonists in diabetic renal disease. Specificities and potencies in inhibiting ET receptor mediated effects; Importance of blood pressure reduction in retarding the progression of diabetic nephropathy; Effects of selective and non-selective ET antagonists and angiotensin converting enzymes inhibitors on growth factor expression in experimental diabetes.