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Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: in vitro reactivation of red blood cell acetyicholinesterase inhibitied by pa raoxon.

Authors :
Petroianu, G. A.
Arafat, K.
Kuča, K.
Kassa, J.
Source :
Journal of Applied Toxicology; Jan/Feb2006, Vol. 26 Issue 1, p64-71, 8p, 6 Charts, 6 Graphs
Publication Year :
2006

Abstract

The article presents a study which compared the importance of oximes and pralidoxime (PRX) for in vitro reactivation of red blood cell acetylcholinesterase inhibited by paraoxon (POX), a non-neuropathic organophosphate. The study found that the new cholinesterase reactivators are superior to PRX, methoxime and B1-6, K-27 oximes. It discovered the importance of in vivo testing in determining the efficacy of new oximes in treating organophosphorus compounds-induced poisoning.

Details

Language :
English
ISSN :
0260437X
Volume :
26
Issue :
1
Database :
Complementary Index
Journal :
Journal of Applied Toxicology
Publication Type :
Academic Journal
Accession number :
52047284
Full Text :
https://doi.org/10.1002/jat.1108