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Neuronal growth-inhibitory factor (metallothionein-3): structure–function relationships.
- Source :
- FEBS Journal; Jul2010, Vol. 277 Issue 14, p2912-2920, 9p, 4 Diagrams
- Publication Year :
- 2010
-
Abstract
- Neuronal growth-inhibitory factor (GIF), also named metallothionein-3, inhibits the outgrowth of neuronal cells. Recent studies on the structure of human GIF, carried out using NMR and molecular dynamics simulation techniques, have been summarized. By studying a series of protein-engineered mutants of GIF, we showed that the bioactivity of GIF is modulated by multiple factors, including the unique TCPCP motif-induced characteristic conformation, the solvent accessibility and dynamics of the metal–thiolate cluster, and the domain–domain interactions. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1742464X
- Volume :
- 277
- Issue :
- 14
- Database :
- Complementary Index
- Journal :
- FEBS Journal
- Publication Type :
- Academic Journal
- Accession number :
- 51877633
- Full Text :
- https://doi.org/10.1111/j.1742-4658.2010.07716.x