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Cytotoxic saponins from the root of Dipsacus asper wall.
- Source :
- Archives of Pharmacal Research; Sep2005, Vol. 28 Issue 9, p1053-1056, 4p
- Publication Year :
- 2005
-
Abstract
- Cytotoxic activity of seven hederagenin saponins isolated from the root of Dipsacus asper were investigated in vitro against L1210, HL-60, and SK-OV-3 tumor cell lines by the MTT method. 3- O-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl hederagenin ( 2), 3- O-β-D-xylopyranosyl-(1→3)-α-L-Rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl hederagenin ( 6) and 3- O-β-D-glucopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl hederagenin ( 7) exhibited the potent cytotoxicity against the three tumor cell lines with IC<subscript>50</subscript> values ranging from 4.7 to 8.7 μg/mL, with the exception of compound 7, which exhibited weak cytotoxic activity against SK-OV-3 (IC<subscript>50</subscript> 22.5 μg/mL). Other compounds did not exhibit any cytotoxic activity (IC<subscript>50</subscript>>30 μg/mL). [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02536269
- Volume :
- 28
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Archives of Pharmacal Research
- Publication Type :
- Academic Journal
- Accession number :
- 51628347
- Full Text :
- https://doi.org/10.1007/BF02977401