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P element regulation and X-chromosome subtelomeric heterochromatin in Drosophila melanogaster.
- Source :
- Genetica; Mar1997, Vol. 100 Issue 1-3, p95-107, 13p
- Publication Year :
- 1997
-
Abstract
- In Drosophila melanogaster, crossing males carrying autonomous P elements with females devoid of P copies results in hybrid dysgenesis in the germline of progeny. The reciprocal cross produces non-dysgenic progeny due to a maternally inherited state non-permissive for P transposition. The capacity of a P copy to repress transposition depends on both its structure and its chromosomal location. Naturally occuring regulatory P elements inserted at the telomere of the X chromosome have been genetically isolated in a genomic context devoid of other P elements. One or two copies of autonomous P elements at this site (1A) are sufficient to elicit a strong P repression in the germline. These elements are flanked by Telomeric Associated Sequences, previously identified and described by Karpen and Spradling (1992) as having heterochromatic properties. The regulatory properties of P elements at 1A are strongly impaired by mutations affecting Su(var)205, which encodes Heterochromatin Protein 1, a non-histone heterochromatin protein. The regulatory properties of classical P strains are not sensitive to Su(var)205. Models based on chromatin structure or on nuclear localisation of the telomeres are discussed in order to explain both the strong regulatory properties of P elements at the X chromosome telomere and their sensitivity to Su(var)205. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00166707
- Volume :
- 100
- Issue :
- 1-3
- Database :
- Complementary Index
- Journal :
- Genetica
- Publication Type :
- Academic Journal
- Accession number :
- 51592607
- Full Text :
- https://doi.org/10.1023/A:1018356906932