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Functional Anatomy of T Cell Activation and Synapse Formation.
- Source :
- Annual Review of Immunology; 2010, Vol. 28, p79-105, 17p
- Publication Year :
- 2010
-
Abstract
- T cell activation and function require a structured engagement of antigen-presenting cells. These cell contacts are characterized by two distinct dynamics in vivo: transient contacts resulting from promigratory junctions called immunological kinapses or prolonged contacts from stable junctions called immunological synapses. Kinapses operate in the steady state to allow referencing to self-peptide-MHC (pMHC) and searching for pathogen-derived pMHC. Synapses are induced by T cell receptor (TCR) interactions with agonist pMHC under specific conditions and correlate with robust immune responses that generate effector and memory T cells. High-resolution imaging has revealed that the synapse is highly coordinated, integrating cell adhesion, TCR recog- nition of pMIC complexes, and an array of activating and inhibitory ligands to promote or prevent T cell signaling. In this review, we examine the molecular components, geometry, and timing underlying kinapses and synapses. We integrate recent molecular and physiological data to provide a synthesis and suggest ways forward. [ABSTRACT FROM AUTHOR]
- Subjects :
- T cells
SYNAPSES
CELLS
PATHOGENIC microorganisms
CELL adhesion
Subjects
Details
- Language :
- English
- ISSN :
- 07320582
- Volume :
- 28
- Database :
- Complementary Index
- Journal :
- Annual Review of Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 50446154
- Full Text :
- https://doi.org/10.1146/annurev-Immunol-030409-101308