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Pudendal denervation affects the structure and function of the striated, urethral sphincter in female rats.
- Source :
- International Urogynecology Journal; Apr1998, Vol. 9 Issue 2, p88-93, 6p
- Publication Year :
- 1998
-
Abstract
- Our aim was to examine the effects of denervation on urethral anatomy and urine voiding pattern. Rats usually void at one end of their cage, which gives a behavioral index of continence. The voiding preference for denervated rats was decreased to 88.8+4.7%, n=32, P<0.001, compared to improvements with time for unoperated (117±10%, n=16) or sham-operated rats (105±8%, n=5). The volume of urine or the frequency of voidings between denervated, unoperated or sham-operated rats did not differ significantly. Urethral sections were analyzed immunochemically and quantified morphometrically. Smooth muscle volume remained constant but skeletal muscle volume decreased after denervation, from 43±2% to 36±3% ( P<0.05, n=5). Fiber diameter decreased from 14.3±1.4 μm to 8.5±0.7 μm ( P<0.005). We concluded that pudendal nerve transection in female rats causes behavioral alterations in voiding and muscular atrophy of the striated sphincter. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09373462
- Volume :
- 9
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- International Urogynecology Journal
- Publication Type :
- Academic Journal
- Accession number :
- 50001278
- Full Text :
- https://doi.org/10.1007/BF01982215