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Pudendal denervation affects the structure and function of the striated, urethral sphincter in female rats.

Authors :
Heidkamp, M.
Leong, F.
Brubaker, L.
Russell, B.
Source :
International Urogynecology Journal; Apr1998, Vol. 9 Issue 2, p88-93, 6p
Publication Year :
1998

Abstract

Our aim was to examine the effects of denervation on urethral anatomy and urine voiding pattern. Rats usually void at one end of their cage, which gives a behavioral index of continence. The voiding preference for denervated rats was decreased to 88.8+4.7%, n=32, P<0.001, compared to improvements with time for unoperated (117±10%, n=16) or sham-operated rats (105±8%, n=5). The volume of urine or the frequency of voidings between denervated, unoperated or sham-operated rats did not differ significantly. Urethral sections were analyzed immunochemically and quantified morphometrically. Smooth muscle volume remained constant but skeletal muscle volume decreased after denervation, from 43±2% to 36±3% ( P<0.05, n=5). Fiber diameter decreased from 14.3±1.4 μm to 8.5±0.7 μm ( P<0.005). We concluded that pudendal nerve transection in female rats causes behavioral alterations in voiding and muscular atrophy of the striated sphincter. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09373462
Volume :
9
Issue :
2
Database :
Complementary Index
Journal :
International Urogynecology Journal
Publication Type :
Academic Journal
Accession number :
50001278
Full Text :
https://doi.org/10.1007/BF01982215