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Alterations in extracellular matrix components in transplant glomerulopathy.

Authors :
Jeong, Hyeon Joo
Sung, Sun Hee
Hong, Soon Won
Moon, Jang Il
Kim, Soon Il
Kim, Yu Seun
Park, Kiil
Jeong, H J
Sung, S H
Hong, S W
Moon, J I
Kim, S I
Kim, Y S
Park, K
Source :
Virchows Archiv: European Journal of Pathology; Jul2000, Vol. 437 Issue 1, p69-73, 5p
Publication Year :
2000

Abstract

The distribution pattern of extracellular matrix (ECM) components in transplant glomerulopathy was studied in relation to light microscopic features, actin expression of mesangial cells, and intraglomerular inflammatory cells. Nine cases of mild (group I) and nine cases of severe (group II) transplant glomerulopathy were stained with antisera against fibronectin (FN), tenascin (TN), collagen types III and IV, smooth muscle actin, CD45RO, CD68, and Ki-67 antigen. The composition of ECM was similar in the two groups. The expanded mesangium was diffusely stained by type-IV collagen, FN and TN, and focally and weakly stained by type-III collagen and smooth muscle actin. Type-IV collagen was linearly stained along the capillary walls, imparting a double-contour feature, whereas FN and TN showed granular staining along the capillary walls. CD68 positive cells were increased in severe transplant glomerulopathy, but this increase was not related to ECM deposition. These findings suggest that increased glomerular deposition of normal and abnormal ECM components participate in the evolution of transplant glomerulopathy. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09456317
Volume :
437
Issue :
1
Database :
Complementary Index
Journal :
Virchows Archiv: European Journal of Pathology
Publication Type :
Academic Journal
Accession number :
49994935
Full Text :
https://doi.org/10.1007/s004280000193