Back to Search Start Over

Negative association between metabolic syndrome and bone mineral density in Koreans, especially in men.

Authors :
Ha Young Kim
Jae Won Choe
Hong Kyu Kim
Sung Jin Bae
Beom Jun Kim
Seung Hun Lee
Jung-Min Koh
Ki Ok Han
Hyoung Moo Park
Ghi Su Kim
Kim, Ha Young
Choe, Jae Won
Kim, Hong Kyu
Bae, Sung Jin
Kim, Beom Jun
Lee, Seung Hun
Koh, Jung-Min
Han, Ki Ok
Park, Hyoung Moo
Kim, Ghi Su
Source :
Calcified Tissue International; May2010, Vol. 86 Issue 5, p350-358, 9p, 5 Charts, 2 Graphs
Publication Year :
2010

Abstract

Cardiovascular disease and osteoporosis are thought to share common risk factors, and metabolic syndrome (MS) is composed of major risk factors for cardiovascular disease. This study was performed to investigate the relationships between specific MS components and bone mineral density (BMD). BMD was measured at the femoral neck of Korean men aged 40 years or more (n = 1,780) and postmenopausal women (n = 1,108) using dual-energy X-ray absorptiometry. We identified subjects with MS as defined by two criteria, International Diabetes Federation (IDF) and American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI). Body fat and lean mass were measured via bioimpedance analysis. The prevalence of MS was 19.8% and 7.7% in men and 20.8% and 11.6% in postmenopausal women according to the AHA/NHLBI definition and the IDF definition, respectively. After multivariate adjustment, femoral neck BMD was significantly lower in subjects with MS regardless of diagnostic criteria. BMD decreased as the number of MS components increased (P < 0.001 for trends in both sexes). Among MS components, waist circumference was the most important factor in this negative association. When multiple linear regression models were applied to each 5-kg weight stratum to test for a linear trend, waist circumference and fat mass were negatively associated with BMD and lean mass was positively associated with BMD in men but not in women. MS was associated with a lower BMD in Korean men and postmenopausal women, suggesting that visceral fat may lead to bone loss, especially in men. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
0171967X
Volume :
86
Issue :
5
Database :
Complementary Index
Journal :
Calcified Tissue International
Publication Type :
Academic Journal
Accession number :
49780093
Full Text :
https://doi.org/10.1007/s00223-010-9347-2