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Efficacy of switching to entecavir monotherapy in Japanese lamivudine-pretreated patients.
- Source :
- Journal of Gastroenterology & Hepatology; May2010, Vol. 25 Issue 5, p892-898, 7p, 4 Charts, 1 Graph
- Publication Year :
- 2010
-
Abstract
- Background and Aims: To assess the efficacy of switching Japanese chronic hepatitis B patients from lamivudine monotherapy to entecavir 0.5 mg/day. Methods: A retrospective analysis was conducted on 134 patients switched to entecavir between September 2006 and February 2008 for 6 months or more. Patients were divided into three groups based on viral load at entecavir switching point (baseline < 2.6, 2.6–5.0 and > 5.0 log<subscript>10</subscript> copies/mL). Results: At baseline, detection of lamivudine-resistant virus was highest in patients with higher hepatitis B virus (HBV) DNA (76% vs 23% in ≥ 2.6 and < 2.6 log<subscript>10</subscript> copies/mL, respectively), and in patients with longest previous exposure to lamivudine (52%, 28% and 24% for > 3 years, 1–3 years and < 1 year, respectively). Two years after entecavir switching, HBV DNA suppression to less than 2.6 log<subscript>10</subscript> copies/mL was achieved in 100% (32/32), 92% (12/13) and 44% (4/9) of patients in the less than 2.6, 2.6–5.0 and more than 5.0 log<subscript>10</subscript> copies/mL baseline groups, respectively. Alanine aminotransferase (ALT) normalization occurred in 76–96% and 90–100% of patients following 1 and 2 years of entecavir treatment, respectively. One patient (2.6–5.0 log<subscript>10</subscript> copies/mL) with lamivudine-resistant mutants at baseline developed entecavir resistance at week 48 during follow up. Conclusion: Switching to entecavir 0.5 mg/day achieves or maintains undetectable HBV DNA levels and ALT normalization over 2 years, especially in patients with viral load less than 5.0 log<subscript>10</subscript> copies/mL. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08159319
- Volume :
- 25
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Journal of Gastroenterology & Hepatology
- Publication Type :
- Academic Journal
- Accession number :
- 49773668
- Full Text :
- https://doi.org/10.1111/j.1440-1746.2009.06161.x