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Microvascular protective activity in rabbits of triterpenes from Hylocereus undatus.

Microvascular protective activity in rabbits of triterpenes from Hylocereus undatus.

Authors :
Gutiérrez, Rosa
Solís, Rosario
Baez, Efren
Flores, Jose
Source :
Journal of Natural Medicines; Jul2007, Vol. 61 Issue 3, p296-301, 6p
Publication Year :
2007

Abstract

Two new pentacyclic triterpene taraxast-20-ene-3α-ol ( 1) and taraxast-12,20(30)-dien-3α-ol ( 2) were isolated from chloroform extract of leaves of Hylocereus undatus. These triterpenes showed protective activity against the increase of skin vascular permeability in rabbits. The protective effect, measured as the reduction in leakage of Evans blue, was of 53.5% and 70.1% for 1 and 2, respectively, after peritoneal treatment at a dose of 50 mg/kg. Comparison was made between the action of the compounds and a protective microvascular drug known as troxerutin (64.5%) at the same doses. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
13403443
Volume :
61
Issue :
3
Database :
Complementary Index
Journal :
Journal of Natural Medicines
Publication Type :
Academic Journal
Accession number :
49629870
Full Text :
https://doi.org/10.1007/s11418-007-0150-y