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Pathogenic role and clinical relevance of antineutrophil cytoplasmic antibodies in vasculitides.
- Source :
- Current Rheumatology Reports; Jul2006, Vol. 8 Issue 4, p292-298, 7p
- Publication Year :
- 2006
-
Abstract
- Within the last year, a growing body of evidence for a distinct role of antineutrophil cytoplasmic antibodies (ANCA) in the pathogenesis of ANCA-associated vasculitides (AAV) has developed. An experimental model of myeloperoxidase (MPO)-ANCA-associated vasculitis provided direct and convincing in vivo evidence that MPO-ANCA are primary pathogenic factors in small-vessel vasculitis by augmenting of leukocyte-vessel wall interaction and leukocyte-mediated vascular injury. Determination of bacterial lipopolysaccharide (LPS) effects on disease severity in a mouse model of anti-MPO-induced glomerulonephritis showed that ANCA and other proinflammatory stimuli of infectious origin acted in synergism in the development of destructive inflammation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15233774
- Volume :
- 8
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Current Rheumatology Reports
- Publication Type :
- Academic Journal
- Accession number :
- 49600741
- Full Text :
- https://doi.org/10.1007/s11926-006-0012-8