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Differential time course of effects of κ-opioid agonist treatment on dynorphin a levels and κ-opioid receptor density.
- Source :
- Journal of Molecular Neuroscience; Sep2004, Vol. 24 Issue 2, p307-314, 8p
- Publication Year :
- 2004
-
Abstract
- The effects of κ-opioid agonist treatment on κ-opioid receptor density and on dynorphin A levels in the rat brain were studied. Rats were treated with the selective κ-opioid agonist U-69593 or vehicle for 5 d. Dynorphin A levels and κ-opioid receptor binding were measured on day 8 (3 d after the last injection) or 22 (17 d after the last injection). On day 8, κ-opioid receptor density was increased in the hypothalamus of rats treated with U-69593; there were no changes in the frontal cortex or caudate putamen. In contrast, there was an increase in dynorphin A levels in the frontal cortex and no changes in hypothalamus and caudate putamen in response to U-69593. On day 22, B <subscript>max</subscript> was decreased in frontal cortex and caudate putamen of U-69593-treated rats, whereas dynorphin A levels were increased in the caudate putamen and in the frontal cortex. These findings suggest that κ-opioid receptor agonist treatment has long-term, continually changing effects on the κ-opioid system. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08958696
- Volume :
- 24
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Journal of Molecular Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 49541733
- Full Text :
- https://doi.org/10.1385/JMN:24:2:307