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Vitamin A depletion alters sensitivity of motor behavior to MK-801 in C57BL/6J mice.
- Source :
- Behavioral & Brain Functions; 2010, Vol. 6, p7-16, 10p
- Publication Year :
- 2010
-
Abstract
- Background: Vitamin A and its derivatives (retinoids) are crucial for the development, maintenance and morphogenesis of the central nervous system (CNS). Although motor impairment has been reported in postnatal vitamin A depletion rodents, the effect of vitamin A depletion on homeostasis maintaining capability in response to external interference is not clear. Methods: In the current study, we measured the effect of vitamin A depletion on motor ability and pain sensitivity under two different conditions: 1. prior to any injection and 2. after the injection of an N-methyl-D-aspartate (NMDA) receptor antagonist (MK-801). Results: Vitamin A depletion mice showed decreased body weight, enhanced locomotor activity, increased rearing and less tail flick latency. Vitamin A depletion also induced hypersensitivity of stereotypy, ataxia, rearing, and tail flick latency to MK-801, but hyposensitivity of locomotion to MK-801. Conclusions: These findings suggest that vitamin A depletion affect broad basal behavior and disrupt homeostasis maintaining capability in response to glutamate perturbation. We provide a useful animal model for assessing the role of vitamin A depletion in regulating animal behavior, and for detecting how neurotransmitter pathways might be involved in vitamin A depletion related behavioral abnormalities. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17449081
- Volume :
- 6
- Database :
- Complementary Index
- Journal :
- Behavioral & Brain Functions
- Publication Type :
- Academic Journal
- Accession number :
- 49153522
- Full Text :
- https://doi.org/10.1186/1744-9081-6-7