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Reversed Mutation Rates of KRAS and EGFR Genes in Adenocarcinoma of the Lung in Taiwan and Their Implications.

Authors :
Chun-Chieh Wu
Hui-Yu Hsu
Hui-Ping Liu
Chang, John Wen-Cheng
Ya-Ting Chen
Wen-Yu Hsieh
Jia-Juan Hsieh
Meng-Shu Hsieh
Yi-Rong Chen
Shiu-Feng Huang
Source :
Cancer (0008543X); 12/1/2008, Vol. 113 Issue 11, p3199-3208, 10p, 4 Charts, 1 Graph
Publication Year :
2008

Abstract

The article presents a study which discusses the mutation rates of Kirsten ras oncogene homolog gene (KRAS) among patients with nonsmall cell lung cancer (NSCLC). It mentions that the researchers performed mutation analysis of KRAS and correlated its results with clinicopathological features. It affirms that the authors concluded that the KRAS mutation rate is too low in terms of being considered as an important factor in resisting tyrosine kinase inhibitor (TKI).

Details

Language :
English
ISSN :
0008543X
Volume :
113
Issue :
11
Database :
Complementary Index
Journal :
Cancer (0008543X)
Publication Type :
Academic Journal
Accession number :
49095853
Full Text :
https://doi.org/10.1002/cncr.23925