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Best-corrected visual acuity and frequency of ocular attacks during the initial 10 years in patients with Behçet’s disease.

Authors :
Kaburaki, Toshikatsu
Araki, Fumiyuki
Takamoto, Mitsuko
Okinaga, Kimiko
Yoshida, Atsushi
Numaga, Jiro
Fujino, Yujiro
Kawashima, Hidetoshi
Source :
Graefe's Archive of Clinical & Experimental Ophthalmology; May2010, Vol. 248 Issue 5, p709-714, 6p, 1 Chart, 5 Graphs
Publication Year :
2010

Abstract

Recent publications have suggested considerable improvements in the clinical outcomes of ocular Behcet’s disease (BD) patients. However, the long-term time course of clinical ocular features of BD in recent cases remains largely unknown. In this study, we investigated annual time-course changes of best-corrected visual acuity (BCVA) during ocular convalescent stages, as well as annual frequency of ocular attacks during the initial 10 years of follow-up in patients with BD. We studied 75 eyes in 39 patients (31 men, eight women) with BD, who were referred to our hospital between 1980 and 1996 within 1 year after the initial ocular attack and followed them up continuously for more than 10 years. The clinical courses of BCVA at the ocular convalescent stage from the onset of ocular disease were retrospectively examined, and the numbers of ocular attacks per eye per year were determined. Mean BCVA was 0.59 at 1 year, 0.31 at 3 years, and 0.12 at 10 years from the onset of ocular disease, while the numbers of ocular attacks per eye were 4.1 ± 3.1 at 1 year, 2.2 ± 1.9 at 5 years, and 1.4 ± 1.8 at 10 years. Ocular attacks were still observed in 33 eyes (45%) of 21 patients (54%) with BD even after 10 years. Final BCVA in 42 eyes (56%) became lower than 0.5. The major reasons for poor visual prognosis were macular atrophy (41%) and chorioretinal atrophy (26%). The decline of BVCA continued, and nearly half the patients still suffered from ocular attacks at 10 years after the onset of ocular BD. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
0721832X
Volume :
248
Issue :
5
Database :
Complementary Index
Journal :
Graefe's Archive of Clinical & Experimental Ophthalmology
Publication Type :
Academic Journal
Accession number :
48827541
Full Text :
https://doi.org/10.1007/s00417-009-1234-z