Infrared Spectral Linearity of Some Anti-Plasmoidal Potent Chalcones.

Three series of styryl aryl ketones (E-2-propen-1-ones) are synthesized by solvent free method carried out by grinding the benzaldehydes and the aryl methyl ketones in the presence of solid sodium hydroxide. They are characterized by physical constants and spectral data. From infrared spectral data, the deformation modes of C-H in-plane/outof- plane, -CH=CH- and >C=C< out-of-plane of the vinyl parts are assigned. With the help of regression analysis, the deformation modes have been correlated with Hammett substituent constants. From the results of statistical analysis the effects of substituent on the above deformation modes have been explained. The anti-plasmoidal potential is evaluated for the synthesized chalcones. [ABSTRACT FROM AUTHOR]