Mutant IDH1-specific immunohistochemistry distinguishes diffuse astrocytoma from astrocytosis.

The article offers information on how diffuse astrocytomas can be differentiated from astrocytosis (gliosis) on biopsies, particularly small biopsies while diagnosing neuropathology. It informs that challenging differential diagnosis arises in two general situations which includes low cellularity edges of infiltrating astrocytomas verses mild astrocytosis and florid astrocytosis verses cellular astrocytomas. It informs how molecular assays are converted to immunohistochemical stain.