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Analysis of NSAID-Activated Gene 1 Expression in Prostate Cancer.
- Source :
- Urologia Internationalis; Mar2010, Vol. 84 Issue 2, p198-202, 5p, 1 Chart, 4 Graphs
- Publication Year :
- 2010
-
Abstract
- Nonsteroidal anti-inflammatory drugs (NSAIDs) induce expression of NSAID-activated gene 1 (NAG-1). NAG-1 expression in prostate cancer has previously been detected by microarray and immunohistochemical analyses. We examined the mRNA expression of NAG-1 by quantitative real-time polymerase chain reaction using 51 human prostate cancer tissue specimens. The level of NAG-1 expression was higher in prostate cancer than in normal prostate tissues (p = 0.025). The level of NAG-1 expression was also significantly higher in well-differentiated prostate cancer than in moderately (p = 0.04) and poorly differentiated adenocarcinomas (p = 0.03). These data suggest that NAG-1 may be a new biomarker for evaluating the grade of malignancy in prostate cancer. Copyright © 2010 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00421138
- Volume :
- 84
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Urologia Internationalis
- Publication Type :
- Academic Journal
- Accession number :
- 48466155
- Full Text :
- https://doi.org/10.1159/000277599