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Efficacy and safety of cyclosporine A in patients with refractory systemic lupus erythematosus in a daily clinical practice.
- Source :
- Lupus; Feb2010, Vol. 19 Issue 2, p162-169, 8p, 3 Charts, 4 Graphs
- Publication Year :
- 2010
-
Abstract
- We investigated the efficacy and safety of cyclosporine A (CsA; targeted serum trough level: 80-150 ng/ml) in a daily clinical practice for treating patients with systemic lupus erythematosus (SLE), who had been, or were expected to be, refractory to glucocorticoids (GCs) and other immunosuppressants. Fifty-nine patients with SLE receiving CsA were observed for at least 6 months (21.5 months on average). A significant reduction of proteinuria was noted 2 weeks after initiation of treatment in patients with nephritis, resulting in a clinical response in five of eight patients in the GC dose-up group and 11 of 18 patients in the stable GC dose group, respectively. Notably, the mean score for disease activity on the SLE Disease Activity Index decreased significantly from 8.6±5.3 to 4.4±2.5 after CsA treatment in patients in the stable GC dose group (n=40). Moreover, the mean flare rate decreased by approximately 60% with CsA. Side effects of CsA appeared in 32.2% of patients and all of them subsided through dose reduction or discontinuation (n=8) of CsA. Consequently, the cumulative 2-year survival rate of CsA was 75%. The results suggest that CsA should be considered for patients with SLE refractory to GCs. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09612033
- Volume :
- 19
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Lupus
- Publication Type :
- Academic Journal
- Accession number :
- 47713970
- Full Text :
- https://doi.org/10.1177/0961203309350320