Matrix Metalloproteinase 13-Deficient Mice Are Resistant to Osteoarthritic Cartilage Erosion but Not Chondrocyte Hypertrophy or Osteophyte Development.

The article presents a study on the role of matrix metalloproteinase 13 (MMP-13) in osteoarthritis (OA). It is stated in the study that OA prognosis is determined by the erosion of articular cartilage and MMP-13 is responsible for collagen release. It notes that cartilage aggrecan loss and chondrocyte hypertrophy were analyzed in MMP-13-knockout mice and wild-type mice. It also mentions that the study found that cartialge erosion can be inhibited by MMP-13 deficiency with aggrecan depletion.