A Critical Role of Cyr61 in Interleukin-17-Dependent Proliferation of Fibroblast-like Synoviocytes in Rheumatoid Arthritis.

The article presents a study on the role of Cyr61, an extracellular matrix protein, in the fibroblast-like synoviocytes (FLS) proliferation regulation from rheumatoid arthritis (RA) patients. It is stated that cell adhesion, proliferation and differentiation involve Cyr61. It notes that the study analyzed its expression in synovial tissue (ST) and FLS proliferation. It also mentions that the study found Cyr61 overexpression in ST and FLS, indicating that its critical role in the proliferation.