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DNA-psoralen: Single-molecule experiments and first principles calculations.
- Source :
- Applied Physics Letters; 12/21/2009, Vol. 95 Issue 25, p253703, 3p, 1 Color Photograph, 3 Graphs
- Publication Year :
- 2009
-
Abstract
- The authors measure the persistence and contour lengths of DNA-psoralen complexes, as a function of psoralen concentration, for intercalated and crosslinked complexes. In both cases, the persistence length monotonically increases until a certain critical concentration is reached, above which it abruptly decreases and remains approximately constant. The contour length of the complexes exhibits no such discontinuous behavior. By fitting the relative increase of the contour length to the neighbor exclusion model, we obtain the exclusion number and the intrinsic intercalating constant of the interaction. Ab initio calculations are employed in order to provide an atomistic picture of these experimental findings. [ABSTRACT FROM AUTHOR]
- Subjects :
- PSORALENS
DNA
NUCLEIC acids
COUMARINS
DNA probes
Subjects
Details
- Language :
- English
- ISSN :
- 00036951
- Volume :
- 95
- Issue :
- 25
- Database :
- Complementary Index
- Journal :
- Applied Physics Letters
- Publication Type :
- Academic Journal
- Accession number :
- 47132818
- Full Text :
- https://doi.org/10.1063/1.3276555