Time-Dependent Protective Efficacy of Trolox (Vitamin E Analog) Against Microcystin-Induced Toxicity in Tilapia (Oreochromis niloticus).

The article presents a study which examines the effectiveness of Trolox, a vitamin E analog, on the histological and oxidative damage in the organs of tilapia or Oreochromis niloticus. The study investigates the time period efficacy of the vitamin after microcystins (MCs) exposure and the result was evaluated based on lipid peroxidation (LPO), enzymatic and protein oxidation. Findings of the study indicate that the vitamin's higher protective action was observed after one day toxin exposure. It also reveals that the glutathione-S-transferase (GST) activity in the liver was improved by the protecting agent after 24 and 48 hours but the control values were not retrieved. It concludes that its efficacy was more observable after three days of exposure.