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eNOS gene influences platelet phenotype in acute coronary syndrome patients on dual antiplatelet treatment.
- Source :
- Platelets; Dec2009, Vol. 20 Issue 8, p548-554, 7p, 5 Charts
- Publication Year :
- 2009
-
Abstract
- Nitric Oxide (NO) plays a relevant role in regulating platelet recruitment and eNOS is the major isoform known to be expressed in platelets. Polymorphisms in the eNOS gene with a reduced NO availability might affect platelet phenotype. The aim of our study was to evaluate the role of eNOS–786T > C, 894G > T and 4a/4b polymorphisms in modulating platelet phenotype in 1442 acute coronary syndrome (ACS) patients on dual antiplatelet therapy, previously investigated in relation to platelet function. Platelet aggregation on platelet-rich plasma after collagen (2 µg/mL), ADP (10 µM) and arachidonic acid (AA) (1 mM) stimuli and the genetic analysis of eNOS polymorphisms were assessed. In subjects carrying the eNOS 4a and -786C alleles a significantly higher maximal platelet aggregation value after AA was found ( p = 0.02 and p = 0.047, respectively). eNOS 4a but not -786C allele weakly influenced platelet aggregation after collagen stimulus ( p = 0.05). eNOS 4a allele significantly and independently influenced AA-induced platelet aggregation ( p = 0.01). A significantly higher percentage of patients with AA-induced high residual platelet reactivity (RPR) was found in subjects carrying both eNOS 4a and -786C allele ( p = 0.03 and p = 0.04, respectively). At logistic multivariate analysis, the eNOS 4a allele significantly influenced the AA-induced high residual platelet reactivity ( p = 0.02). This study evidences a role for eNOS gene in moderately, but significantly, modulating platelet phenotype in a high-risk population on dual antiplatelet treatment. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09537104
- Volume :
- 20
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Platelets
- Publication Type :
- Academic Journal
- Accession number :
- 45389928
- Full Text :
- https://doi.org/10.3109/09537100903337401