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eNOS gene influences platelet phenotype in acute coronary syndrome patients on dual antiplatelet treatment.

Authors :
Fatini, Cinzia
Sticchi, Elena
Bolli, Paola
Marcucci, Rossella
Giusti, Betti
Paniccia, Rita
Gori, Anna Maria
Gensini, Gian Franco
Abbate, Rosanna
Source :
Platelets; Dec2009, Vol. 20 Issue 8, p548-554, 7p, 5 Charts
Publication Year :
2009

Abstract

Nitric Oxide (NO) plays a relevant role in regulating platelet recruitment and eNOS is the major isoform known to be expressed in platelets. Polymorphisms in the eNOS gene with a reduced NO availability might affect platelet phenotype. The aim of our study was to evaluate the role of eNOS–786T > C, 894G > T and 4a/4b polymorphisms in modulating platelet phenotype in 1442 acute coronary syndrome (ACS) patients on dual antiplatelet therapy, previously investigated in relation to platelet function. Platelet aggregation on platelet-rich plasma after collagen (2 µg/mL), ADP (10 µM) and arachidonic acid (AA) (1 mM) stimuli and the genetic analysis of eNOS polymorphisms were assessed. In subjects carrying the eNOS 4a and -786C alleles a significantly higher maximal platelet aggregation value after AA was found ( p = 0.02 and p = 0.047, respectively). eNOS 4a but not -786C allele weakly influenced platelet aggregation after collagen stimulus ( p = 0.05). eNOS 4a allele significantly and independently influenced AA-induced platelet aggregation ( p = 0.01). A significantly higher percentage of patients with AA-induced high residual platelet reactivity (RPR) was found in subjects carrying both eNOS 4a and -786C allele ( p = 0.03 and p = 0.04, respectively). At logistic multivariate analysis, the eNOS 4a allele significantly influenced the AA-induced high residual platelet reactivity ( p = 0.02). This study evidences a role for eNOS gene in moderately, but significantly, modulating platelet phenotype in a high-risk population on dual antiplatelet treatment. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09537104
Volume :
20
Issue :
8
Database :
Complementary Index
Journal :
Platelets
Publication Type :
Academic Journal
Accession number :
45389928
Full Text :
https://doi.org/10.3109/09537100903337401