Mice trisomic for a bacterial artificial chromosome with the single-minded 2 gene ( Sim2 ) show phenotypes similar to some of those present in the partial trisomy 16 mouse models of Down syndrome.

Tests the hypothesis that overexpression of the single-minded 2 gene (SIM2) contributes to some of the complex Down syndrome phenotypes. Detection and estimation of the Sim2 BAC transgene copy numbers; Expression profile of Sim2 transgene; Characterization of Sim2 transgenic mice.