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Expanded polyglutamine peptides alone are intrinsically cytotoxic and cause neurodegeneration in Drosophila.
- Source :
- Human Molecular Genetics; Jan2000, Vol. 9 Issue 1, p13, 1p, 18 Black and White Photographs, 2 Diagrams, 4 Charts, 1 Graph
- Publication Year :
- 2000
-
Abstract
- Studies the association between expanded polyglutamine (polyQ) peptides and neurodegeneration in Drosophila. Degeneration of sensory bristles; Correlation between the severity of the disease and the length of associated protein sequence; Mechanism of polyQ toxicity reduction by amino acids.
Details
- Language :
- English
- ISSN :
- 09646906
- Volume :
- 9
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Human Molecular Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 4504342
- Full Text :
- https://doi.org/10.1093/hmg/9.1.13