Plasmin Immunization Preferentially Induces Potentially Prothrombotic IgG Anticardiolipin Antibodies in MRL/MpJ Mice.

The article presents a study on the importance of plasmin immunization in the production of immunoglobulin G (IgG) anticardiopolin (aCL) antibodies in patients with antiphospolipid syndrome (APS). It uses two mouse models that were immunized with Freund's complete adjuvant. Results show that BALB/cJ mice only develop IgG antiplasmin, while MRL/MpJ mice had produced IgG antiplasmin and IgG aCL antibodies. It concludes that plasmin immunization can produce prothrombotic aCL in susceptible people.