The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways.

Authors :: Tarricone, C.
Xiao, B.
Justin, N.
Walker, P.A.
Rittinger, K.
Gamblin, S.J.
Smerdon, S.J.
Source :: Nature; 5/10/2001, Vol. 411 Issue 6834, p215, 5p, 3 Diagrams, 2 Graphs
Publication Year :: 2001
Abstract: Focuses on a study which examined the role of the cross-talk between small-G protein families in signaling. Mechanism of Arfaptin (Arf) binding to guanosine triphosphate (GTP)-bound Arf1 and Arf6; Significance of the coordinated action of Arf and Rho family GTPases in cellular processes; X-ray structures of Arfaptin; Differences between the molecular mechanisms of Rho and Ras family signaling.

Subjects :: PROTEIN binding
G proteins
GUANOSINE triphosphatase
BIOCHEMICAL mechanism of action

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