In vivo and in vitro neurotoxic action of plasma ultrafiltrate from uraemic patients.

Background: In order to investigate the aetiology of uraemic neuropathy, we evaluated the neurotoxic activity of plasma from uraemic patients. To this end we prepared a concentrate (1 : 1000) of 2-60 kDa MW compounds from paired filtration dialysis ultrafiltrate and evaluated its activity on peripheral nerve conduction in vivo and in vitro. [ABSTRACT FROM PUBLISHER]