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δ-Opioid receptors protect from anoxic disruption of Na+ homeostasis via Na+ channel regulation.
- Source :
- Cellular & Molecular Life Sciences; Nov2009, Vol. 66 Issue 21, p3505-3516, 12p, 8 Graphs
- Publication Year :
- 2009
-
Abstract
- Hypoxic/ischemic disruption of ionic homeostasis is a critical trigger of neuronal injury/death in the brain. There is, however, no promising strategy against such pathophysiologic change to protect the brain from hypoxic/ischemic injury. Here, we present a novel finding that activation of δ-opioid receptors (DOR) reduced anoxic Na<superscript>+</superscript> influx in the mouse cortex, which was completely blocked by DOR antagonism with naltrindole. Furthermore, we co-expressed DOR and Na<superscript>+</superscript> channels in Xenopus oocytes and showed that DOR expression and activation indeed play an inhibitory role in Na<superscript>+</superscript> channel regulation by decreasing the amplitude of sodium currents and increasing activation threshold of Na<superscript>+</superscript> channels. Our results suggest that DOR protects from anoxic disruption of Na<superscript>+</superscript> homeostasis via Na<superscript>+</superscript> channel regulation. These data may potentially have significant impacts on understanding the intrinsic mechanism of neuronal responses to stress and provide clues for better solutions of hypoxic/ischemic encephalopathy, and for the exploration of acupuncture mechanism since acupuncture activates opioid system. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1420682X
- Volume :
- 66
- Issue :
- 21
- Database :
- Complementary Index
- Journal :
- Cellular & Molecular Life Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 44513717
- Full Text :
- https://doi.org/10.1007/s00018-009-0136-x