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Induction of CD8+ T cell-mediated protective immunity against Trypanosoma cruzi.
- Source :
- International Immunology; Feb1999, Vol. 11 Issue 2, p133-141, 9p
- Publication Year :
- 1999
-
Abstract
- Trypanosoma cruzi was transformed with the Plasmodium yoelii gene encoding the circumsporozoite (CS) protein, which contains the well-characterized CD9+ T cell epitope, SYVPSAEQI. In vivo and in vitro assays indicated that cells infected with the transformed T. cruzi could process and present this malaria parasite-derived class I MHC-restricted epitope. Immunization of mice with recombinant influenza and vaccinia viruses expressing the SYVPSAEQI epitope induced a large number of specific CD8+ T cells that strongly suppressed parasitemia and conferred complete protection against the acute T. cruzi lethal infection. CD8+ T cells mediated this immunity as indicated by the unrelenting parasitemia and high mortality observed in immunized mice treated with anti-CD8 antibody. This study demonstrated, for the first time, that vaccination of mice with vectors designed to induce CD8+ T cells is effective against T. cruzi infection. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 09538178
- Volume :
- 11
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- International Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 44444116
- Full Text :
- https://doi.org/10.1093/intimm/11.2.133