Haemodynamic effects of valsartan in acute renal ischaemia/reperfusion injury.

Background. Acute deterioration of renal function is an important side‐effect of angiotensin‐converting enzyme (ACE) inhibitors, especially if accompanied by other nephrotoxic events. Angiotensin II receptor1 blockers (ARB) are thought to have fewer side‐effects on renal perfusion and function. We examined the effects of valsartan (VAL) on kidney function as well as the contribution of the nitric oxide (NO) system in a rat model of ischaemic acute renal failure (ARF). [ABSTRACT FROM PUBLISHER]