PARP1 is required for adhesion molecule expression in atherogenesis.

Authors :: Von Lukowicz, Tobias
Hassa, Paul O.
Lohmann, Christine
Borén, Jan
Braunersreuther, Vincent
Mach, François
Odermatt, Bernhard
Gersbach, Monika
Camici, Giovanni G.
Stähli, Barbara E.
Tanner, Felix C.
Hottiger, Michael O.
Lüscher, Thomas F.
Matter, Christian M.
Source :: Cardiovascular Research; Apr2008, Vol. 78 Issue 1, p158-166, 9p, 5 Graphs
Publication Year :: 2008
Abstract: Aims: Atherosclerosis is the leading cause of death in Western societies and a chronic inflammatory disease. However, the key mediators linking recruitment of inflammatory cells to atherogenesis remain poorly defined. Poly(ADP-ribose) polymerase 1 (PARP1) is a nuclear enzyme, which plays a role in acute inflammatory diseases. [ABSTRACT FROM PUBLISHER]