Preparation, characterization, and blood compatibility of polylactide-based phospholipid polymer.

l-α-glycerophosphorylcholine (GPC) was obtained by hydrolysis of lecithin extracted from eggs. FT-IR and ¹H-NMR analysis indicated a successful preparation of GPC. Polylactide-based phospholipid polymer (PLLA-PC) was synthesized by ring-opening polymerization of l-lactide in the presence of GPC to improve the cell/material interfacial reaction of PLLA for tissue engineering applications. The yield of the reaction strongly depended on the reaction time. Values above 80% were obtained which are much higher than those reported in literature. Copolymers with the largest molecular weights were obtained at 122 °C for 48 h. The properties and biocompatibility of the PLLA-PC copolymers were characterized. Surface rearrangement was detected due to the dynamic molecular motion according to X-ray photoelectron spectroscopy data. Besides, increase in hydrophilicity and decreases in fibrinogen adsorption and platelet adhesion were observed due to the hydrophilic phosphorylcholine moieties in the copolymer. [ABSTRACT FROM AUTHOR]