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Fischer indole synthesis catalyzed by novel SO3H-functionalized ionic liquids in waterElectronic supplementary information (ESI) available: Further experimental details and results and spectra of ionic liquids. See DOI: 10.1039/b901010f.
- Source :
- Green Chemistry; Aug2009, Vol. 11 Issue 8, p1239-1246, 8p
- Publication Year :
- 2009
-
Abstract
- Novel SO3H-functionalized ionic liquids bearing two alkyl sulfonic acid groups in the imidazolium cations were designed and successfully applied as catalysts for the one-pot Fischer indole synthesis in water medium. The sequence of the catalytic activity observed in the transformation was in good agreement with the Brønsted acidity order determined by the Hammett method. Various types of indoles from single-carbonyl ketones/aldehydes and cyclohexandiones were provided in 68–96% yields using the catalytic system of [(HSO3-p)2im][HSO4]/H2O. The indole products could be conveniently separated from the reaction mixture by filtration and the dissolved catalyst could be regenerated by treatment with a strongly acidic cation exchange resin, which meant the whole process was performed in water without using any organic solvents. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14639262
- Volume :
- 11
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Green Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 43992019
- Full Text :
- https://doi.org/10.1039/b901010f