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Occult hepatitis B virus infection increases hepatocellular carcinogenesis by eight times in patients with non-B, non-C liver cirrhosis: a cohort study.
- Source :
- Journal of Viral Hepatitis; Jun2009, Vol. 16 Issue 6, p437-443, 7p, 2 Charts, 2 Graphs
- Publication Year :
- 2009
-
Abstract
- An impact of serum hepatitis B virus (HBV) DNA on hepatocarcinogenesis has not been investigated in a cohort of patients with non-B, non-C cirrhosis. Eighty-two consecutive Japanese patients with cirrhosis, who showed negative hepatitis B surface antigen and negative anti-hepatitis C virus, were observed for a median of 5.8 years. Hepatitis B virus core (HBc) region and HBx region were assayed with nested polymerase chain reaction. Both of HBc and HBx DNA were positive in 9 patients (11.0%) and both were negative in 73. Carcinogenesis rates in the whole patients were 13.5% at the end of the 5th year and 24.6% at the 10th year. The carcinogenesis rates in the patients with positive DNA group and negative DNA group were 27.0% and 11.8% at the end of the 5th year, and 100% and 17.6% at the 10th year, respectively ( P = 0.0078). Multivariate analysis showed that men ( P = 0.04), presence of HBc and HBx DNA (hazard ratio: 8.25, P = 0.003), less total alcohol intake ( P = 0.010), older age ( P = 0.010), and association of diabetes ( P = 0.005) were independently associated with hepatocellular carcinogenesis. Existence of serum HBV DNA predicted a high hepatocellular carcinogenesis rate in a cohort of patients with non-B, non-C cirrhosis. [ABSTRACT FROM AUTHOR]
- Subjects :
- HEPATITIS B virus
CIRRHOSIS of the liver
LIVER cancer
CARCINOGENESIS
COHORT analysis
Subjects
Details
- Language :
- English
- ISSN :
- 13520504
- Volume :
- 16
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Journal of Viral Hepatitis
- Publication Type :
- Academic Journal
- Accession number :
- 43882269
- Full Text :
- https://doi.org/10.1111/j.1365-2893.2009.01085.x