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Autoimmune autonomic ganglionopathy: treatment by plasma exchanges and rituximab.
- Source :
- Clinical Autonomic Research; Aug2009, Vol. 19 Issue 4, p259-262, 4p, 2 Graphs
- Publication Year :
- 2009
-
Abstract
- This case report describes successful treatment of autoimmune autonomic ganglionopathy (AAG) in a 74-year-old woman by total plasma exchanges (PLEX) and rituximab. Two series of PLEX temporarily, but dramatically improved orthostatic intolerance and hypotension and baroreflex function, in a manner inversely related to ganglionic neuronal nicotinic receptor antibody titer. After rituximab treatment, the antibody titer was decreased modestly but persistently, and the patient had symptomatic and clinical laboratory evidence of continued benefit for at least 10 months, supporting the autoimmune pathogenesis of AAG. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09599851
- Volume :
- 19
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Clinical Autonomic Research
- Publication Type :
- Academic Journal
- Accession number :
- 43534868
- Full Text :
- https://doi.org/10.1007/s10286-009-0012-7