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Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma.
- Source :
- Nature Genetics; Aug2009, Vol. 41 Issue 8, p873-875, 3p, 1 Chart, 1 Graph
- Publication Year :
- 2009
-
Abstract
- We conducted genome-wide association studies of non-Hodgkin lymphoma using Illumina HumanHap550 BeadChips to identify subtype-specific associations in follicular, diffuse large B-cell and chronic lymphocytic leukemia/small lymphocytic lymphomas. We found that rs6457327 on 6p21.33 was associated with susceptibility to follicular lymphoma (FL; N = 189 cases, 592 controls) with validation in another 456 FL cases and 2,785 controls (combined allelic P = 4.7 × 10<superscript>−11</superscript>). The region of strongest association overlapped C6orf15 (STG), located near psoriasis susceptibility region 1 (PSORS1). [ABSTRACT FROM AUTHOR]
- Subjects :
- DISEASE susceptibility
LYMPHOMAS
LEUKEMIA
PSORIASIS
CLINICAL trials
Subjects
Details
- Language :
- English
- ISSN :
- 10614036
- Volume :
- 41
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Nature Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 43433880
- Full Text :
- https://doi.org/10.1038/ng.419