Kramers-like turnover in load-dependent activated dynamics.

Recent advancement of experimental techniques at the single molecule level has demonstrated how an external load affects a chemical reaction which controls the transport of biological motor proteins. Majority of these studies are concerned with thermodynamically open systems. We have examined a prototype model reaction in terms of inertial Brownian motion of a particle in a force field subjected to an overdamped motion of a viscous load coupled harmonically to the particle. A general analytical expression for the rate constant has been derived to demonstrate that depending on the strength of harmonic coupling and drag coefficient of the load a Kramers-like turnover can be realized in the spatial diffusion-limited regime. The turnover reduces to a crossover between the two states characterized by zero-load and finite load conditions. [ABSTRACT FROM AUTHOR]