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Structure of IRF-1 with bound DNA reveals determinants of interferon regulation.
- Source :
- Nature; 1/1/1998, Vol. 391 Issue 6662, p103, 4p, 5 Color Photographs, 4 Diagrams, 1 Chart
- Publication Year :
- 1998
-
Abstract
- Presents research which reported the crystal structure of the interferon regulatory factor (IRF)-1 region bound to the natural positive regulatory domain I (PRD I) DNA element from the interferon-beta promoter. Importance of IRF transcription factors and their DNA-binding region; Details about structure; Suggested basis for occurrence of GAAA repeats within IRF response elements; Assembly of interferon-beta enhancesome.
Details
- Language :
- English
- ISSN :
- 00280836
- Volume :
- 391
- Issue :
- 6662
- Database :
- Complementary Index
- Journal :
- Nature
- Publication Type :
- Academic Journal
- Accession number :
- 42902
- Full Text :
- https://doi.org/10.1038/34224