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Protective effect of melatonin against the inflammatory response elicited by crude venom from isolated nematocysts of Pelagia noctiluca (Cnidaria, Scyphozoa).

Authors :
Marino, Angela
Di Paola, Rosanna
Crisafulli, Concetta
Mazzon, Emanuela
Morabito, Rossana
Paterniti, Irene
Galuppo, Maria
Genovese, Tiziana
La Spada, Giuseppina
Cuzzocrea, Salvatore
Source :
Journal of Pineal Research; Aug2009, Vol. 47 Issue 1, p56-69, 14p, 1 Color Photograph, 1 Diagram, 5 Graphs
Publication Year :
2009

Abstract

Melatonin (N-acetyl-5-methoxytryptamine) is an efficient free radical scavenger and antioxidant, both in vitro and in vivo. The role of melatonin as an immunomodulator is, in some cases, contradictory. In this study we have investigated the therapeutic efficacy of melatonin in rats subjected to Pelagia noctiluca crude venom (of the familia Pelaguiidae; and genus Pelagia) induced acute paw inflammation. In particular, injection of the venom into the paw of rats elicited an acute inflammatory response characterized by accumulation of fluid containing a large number of polymorphonuclear neutrophils in the paw and subsequent lipid peroxidation. Furthermore, the venom promoted an expression of iNOS, nitrotyrosine and the activation of the nuclear enzyme poly (ADP-ribose) polymerase as determined by immunohistochemical analysis of paw tissues. Administration of melatonin 30 min, 1 and 6 hr after the challenge with the venom, caused a significant reduction in all the parameters of inflammation measured. Thus, based on these findings we propose that melatonin may be useful a treatment of local acute inflammation induced by P. noctiluca crude venom. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
07423098
Volume :
47
Issue :
1
Database :
Complementary Index
Journal :
Journal of Pineal Research
Publication Type :
Academic Journal
Accession number :
42874418
Full Text :
https://doi.org/10.1111/j.1600-079X.2009.00688.x