Targeted Disruption of the CXCL12/CXCR4 Axis Inhibits Osteolysis in a Murine Model of Myeloma-Associated Bone Loss.

Authors :: Diamond, Peter
Labrinidis, Agatha
Martin, Sally K.
Farrugia, Amanda N.
Gronthos, Stan
To, L. Bik
Fujii, Nobutaka
O'Loughlin, Peter D.
Evdokiou, Andreas
Zannettino, Andrew C. W.
Source :: Journal of Bone & Mineral Research; Jul2009, Vol. 24 Issue 7, p1150-1161, 12p, 1 Diagram, 1 Chart, 5 Graphs
Publication Year :: 2009
Abstract: The article discusses the results of a study on the role of CXCL12/CXCR4 chemokines in the activation and migration of osteoclast (OC) associated with bone loss in multiple myeloma (MM) in mice. The study found that overexpression of CXCL12 and RANKL genes in RPMI-8226 cells increased bone resorption mediated by OC. Implantation of RPMI-8226 cells led to osteolytic lesions. It concluded that mediated disruption of CXCL12/CXCR4 limits osteolysis in mice.

Full Text Access

Tools