Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase.

Authors :: Ying Zhang
Chenbei Chang
Gehling, Daniel J.
Hemmati-Brivanlou, Ali
Derynck, Rik
Source :: Proceedings of the National Academy of Sciences of the United States of America; 01/30/2001, Vol. 98 Issue 3, p974, 6p, 24 Black and White Photographs, 1 Chart, 4 Graphs
Publication Year :: 2001
Abstract: Reports on the identification of Smurftwo, a member of the Hect family of ubiquitin ligases. Selective interaction of Smurftwo with receptor-regulated Smads; Preferential targeting of Smadone for ubiquitination and proteasome-mediated degradation; Effect of Smurftwo expression on embryonic patterning by bone morphogenetic protein signals.

Language :: English
ISSN :: 00278424
Volume :: 98
Issue :: 3
Database :: Complementary Index
Journal :: Proceedings of the National Academy of Sciences of the United States of America
Publication Type :: Academic Journal
Accession number :: 4244282
Full Text :: https://doi.org/10.1073/pnas.98.3.974