Mutations of mitotic checkpoint genes in human cancers.

Authors :: Cahill, Daniel P.
Lengauer, Christoph
Yu, Jian
Riggins, Gregory J.
Willson, James K. V.
Markowitz, Sanford D.
Kinzler, Kenneth W.
Vogelstein, Bert
Source :: Nature; 3/19/1998, Vol. 392 Issue 6673, p300, 4p, 4 Color Photographs, 2 Black and White Photographs, 4 Diagrams, 1 Chart, 8 Graphs
Publication Year :: 1998
Abstract: Presents research which showed that chromosomal instability (CIN) is consistently associated with the loss of function of a mitotic checkpoint in human cancers. Genetic instability and neoplasia in two different forms; CIN and aneuploidy; Impact of loss of mitotic checkpoint; Role of BUB1 gene; How normal mitotic checkpoints become defective.